Ceftriaxone Impurity 18
7-Aminocephalosporanic acid
CAS: 957-68-6
Molecular Formula: C10H12N2O5S
Ceftriaxone Impurity 18 - Names and Identifiers
| Name | 7-Aminocephalosporanic acid |
| Synonyms | 7-ACA 7-ACA Impurity Aminocephalosporanic Ceftriaxone Impurity 18 Cefazolin EP Impurity H 7-Aminocephalosporanic acid Cefazolin Sodium EP Impurity H (7-Aminocephalosporanic Acid) 3-(Acetoxymethyl)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-amino-8-oxo- (6R,7R)-3-(acetyloxymethyl)-7-ammonio-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| CAS | 957-68-6 |
| EINECS | 213-485-0 |
| InChI | InChI=1/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)/t6-,9-/m1/s1 |
| InChIKey | HSHGZXNAXBPPDL-HZGVNTEJSA-N |
Ceftriaxone Impurity 18 - Physico-chemical Properties
| Molecular Formula | C10H12N2O5S |
| Molar Mass | 272.28 |
| Density | 1.4667 (rough estimate) |
| Melting Point | >300 °C (lit.) |
| Boling Point | 560.6±50.0 °C(Predicted) |
| Specific Rotation(α) | 94 º (c=0.5, KH2PO4, PH 7) |
| Flash Point | 292.9°C |
| Water Solubility | 409.6mg/L(22.99 ºC) |
| Solubility | DMSO (Very Slightly, Heated) |
| Vapor Presure | 4.87E-14mmHg at 25°C |
| Appearance | Crystallization |
| Color | Off-white to beige |
| Merck | 14,434 |
| BRN | 622638 |
| pKa | 2.59±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| Refractive Index | 1.5650 (estimate) |
| MDL | MFCD00005177 |
| Physical and Chemical Properties | Crystals. |
| Use | Used as a pharmaceutical Intermediate |
Ceftriaxone Impurity 18 - Risk and Safety
| Risk Codes | R42/43 - May cause sensitization by inhalation and skin contact. R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29349960 |
Ceftriaxone Impurity 18 - Introduction
7-Aminocephalosporanic acid is a broad-spectrum antibiotic, also known as Ceftiofur. The following is a description of the nature, use, formulation and safety information of 7-Aminocephalosporanic acid:
Nature:
-chemical formula: C19H17N5O7S3
-Molecular weight: 523.56g/mol
-Appearance: White or off-white crystalline powder
-Solubility: Slightly soluble in water, soluble in ethanol and dimethylformamide
-Stability: relatively stable under dry conditions, but may decompose under strong light
Use:
- 7-Aminocephalosporanic acid is a veterinary drug widely used to treat respiratory and urinary tract infections in poultry and livestock animals
-In the agricultural field, it is also used to prevent and treat bacterial infections in animals, especially those sensitive to penicillin and cephalosporins
Preparation Method:
The preparation method of-7-Aminocephalosporanic acid mainly involves the reaction of cefalexin with 5-aminothiazole-4-carboxylic acid to form cefotaxime.
Safety Information:
- 7-Aminocephalosporanic acid is generally safe under correct use, but it may still cause some adverse reactions.
-The dosage and administration guidelines must be strictly followed when using to minimize the risk of side effects.
-Prevention of allergic reactions is very important, especially for patients who are allergic to beta-lactam antibiotics.
-For humans, direct contact and intake of 7-Aminocephalosporanic acid should be avoided.
-When using agricultural and veterinary drugs, you must follow relevant regulations and use guidelines, and pay attention to the safety of protecting the environment and human health.
Nature:
-chemical formula: C19H17N5O7S3
-Molecular weight: 523.56g/mol
-Appearance: White or off-white crystalline powder
-Solubility: Slightly soluble in water, soluble in ethanol and dimethylformamide
-Stability: relatively stable under dry conditions, but may decompose under strong light
Use:
- 7-Aminocephalosporanic acid is a veterinary drug widely used to treat respiratory and urinary tract infections in poultry and livestock animals
-In the agricultural field, it is also used to prevent and treat bacterial infections in animals, especially those sensitive to penicillin and cephalosporins
Preparation Method:
The preparation method of-7-Aminocephalosporanic acid mainly involves the reaction of cefalexin with 5-aminothiazole-4-carboxylic acid to form cefotaxime.
Safety Information:
- 7-Aminocephalosporanic acid is generally safe under correct use, but it may still cause some adverse reactions.
-The dosage and administration guidelines must be strictly followed when using to minimize the risk of side effects.
-Prevention of allergic reactions is very important, especially for patients who are allergic to beta-lactam antibiotics.
-For humans, direct contact and intake of 7-Aminocephalosporanic acid should be avoided.
-When using agricultural and veterinary drugs, you must follow relevant regulations and use guidelines, and pay attention to the safety of protecting the environment and human health.
Last Update：2024-04-10 22:29:15
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